The Skyla Hi CRP reagent kit is an immunoassay used with Skyla Hi Analyzer which provides quantitative measurement of C-Reactive Protein (CRP) concentration in human serum, plasma, and whole blood. The test result provides information for the evaluation of infection, tissue injury, inflammatory disorders, and associated diseases. CRP is one of the cytokine-induced acute-phase proteins. The level of CRP in the blood normally below 5 mg/L in healthy person, and above 10 mg/L is typically considered to be clinically significant. This threshold is often exceeded within four to eight hours after an acute inflammatory event, with CRP values reaching approximately 20 to 500 mg/L. Additionally, NICE guidelines also recommend the use of CRP results to guide antibiotic prescribing. Immediate antibiotic treatment should be offered if the CRP level is more than 100 mg/L and a delayed prescription should be considered at levels between 20 and 100 mg/L. Antibiotics are not recommended for CRP levels less than 20 mg/L.